Our lab investigates how bone cells sense and respond to physical forces to maintain skeletal integrity. By utilizing advanced imaging and mechanical testing, we explore the molecular pathways that translate mechanical signals into new bone formation. This work is critical for developing interventions that can mimic the benefits of exercise for patients with limited mobility.

Osteogenesis Imperfecta (OI), or "brittle bone disease," is a genetic disorder characterized by bone fragility and frequent fractures. Our research focuses on identifying novel pharmacological targets to improve bone quality and reduce fracture risk in OI patients. We examine the interplay between collagen mutations and bone mineral density to evaluate the efficacy of emerging therapeutic agents.

We study the dynamic process of skeletal modeling to understand how bones achieve their final size, shape, and strength during maturation. This research tracks the spatial and temporal changes in bone geometry and microarchitecture from early development through adulthood. By mapping these patterns, we aim to identify the windows of opportunity where clinical interventions can most effectively optimize lifelong skeletal health.